Ngo-April 15, 2022, ukukhiqizwa komshayeli we-Lecardipine hydrochloride main ring kwaqedwa ngesikhathi esisodwa, futhi umthamo wamanje wokukhiqiza ungu-5Mt/ ngenyanga.
Igama lesiNgisi:Lercanidipine hydrochloride
Igama lekhemikhali:I-1,4-Dihydro-2,6-dimethyl-4- (3-nitrophenyl) -3,5-pyridinedicarboxylic acid 2--[(3,3-di phenylpropyl)methylamino]-l,l-dimethylethyl methyl ester hydrochloride.
Inombolo ye-CAS: 132866-11-6
Isicelo:Ukuze ukwelashwa kwemithi ye-Lecardipine hydrochloride, ngeke ibe nomphumela omubi kushukela wegazi kanye namazinga e-lipid, futhi inomphumela oqinile we-antihypertensive.
Ithemba lemakethe:
Kuneziguli ezingaphezu kwezigidi ezingama-200 ezinomfutho wegazi ophakeme eShayina, futhi kuneziguli ezintsha ezinomfutho wegazi ophakeme eziyizigidi eziyi-10 minyaka yonke, iningi lazo ezingalawuleki, okuholela esimeni esiphezulu sezinkinga zomfutho wegazi ophakeme njenge-stroke, nokufa konyaka eChina Phakathi kwe-3 izigidi zeziguli ezinesifo senhliziyo, ama-50% ahlobene nomfutho wegazi ophakeme, kanti izindleko zonyaka zokwelashwa kwezifo zenhliziyo zingama-yuan ayizigidi eziyizinkulungwane ezingama-309.8.Isizathu sokungalawuleki kahle akukona nje kuphela ukuthi ukuqwashisa kweziguli ngomfutho wegazi ophezulu kanye nezinkinga zawo kudinga ukuthuthukiswa, kodwa nokuthi iziguli eziningi ezidinga ukuphuza imithi yokuphila kwazo zonke azilandeli kahle futhi azikwazi ukuphuza imithi nsuku zonke Nokho, lokhu kukhombisa nokuthi Imakethe yezidakamizwa ezilwa nomfutho wegazi ophakeme inokunwebeka okungenzeka.Uma kuqhathaniswa nezidakamizwa ezifanayo, i-locarbodipine hydrochloride inokukhetha okunamandla kwemithambo.Impahla yayo eyingqayizivele ye-lipophilic iyenza iphuze futhi ingapheli umphumela we-antihypertensive Umphumela we-atherogenic, ofaneleka ngokukhethekile iziguli ezinomfutho wegazi ophakeme ezine-atherosclerosis, unenani eliphezulu lokusetshenziswa komtholampilo kanye nethemba elibanzi lemakethe.
Isenzo se-Pharmacological:
I-Lecardipine iyisizukulwane esisha se-dihydropyridine calcium channel group hysteresis agent, enokukhetha okunamandla kwe-vascular, umphumela omnene, umphumela oqinile we-antihypertensive, isikhathi eside sesenzo, umphumela omubi omncane we-inotropic nokunye.Ucwaningo lwe-in vitro luthole ukuthi i-locarbodipine inomphumela wokuphumula oqondile emisipha ebushelelezi ye-vascular, ngakho-ke inomphumela oqinile we-antihypertensive ku-vivo, kodwa inomthelela omncane ekushayeni kwenhliziyo nokuphuma kwenhliziyo.Ngenxa yofuzo lwayo olukhulu lwe-hydrophobic kanye ne-lipid solubility eqinile, i-locarbodipine isatshalaliswa ngokushesha ezicutshini nasezithweni ngemuva kokungena emzimbeni, ibophezela eduze kwe-vascular smooth muscle cell membrane, futhi idedele kancane.Ngakho-ke, nakuba i-serum yalesi sidakamizwa inesikhathi esifushane sokuqeda ukwehluleka kwesigamu, umphumela wayo uhlala isikhathi eside.
Isikhathi sokuthumela: Apr-15-2022