I-Sitagliptin phosphate iyisigaba se-dipeptidyl peptidase Ⅳ(DDP-4) inhibitor yezidakamizwa ezakhiwe yinkampani yaseJalimane i-Merck futhi yaqale yathola imvume ye-US Food and Drug Administration yokwelapha uhlobo lwesifo sikashukela sohlobo 2, umuthi omusha we-antidiabetic, ongathuthukisa umzimba amandla okwehlisa amazinga kashukela aphezulu egazini, kanye nokwenyuka ngokwejwayelekile kwe-incretin eyenzeka ngokwemvelo ngokuvimbela umsebenzi wale enzyme, okuhlanganisa amazinga e-glucagon-like peptide 1 kanye ne-insulinotropic peptide encike ku-glucose, ngaleyo ndlela kubangele ama-pancreas ukuthi athuthukise ukukhiqizwa kwe-insulin futhi amise ushukela. ukukhiqizwa esibindini, futhi ekugcineni kunciphise umphumela womtholampilo wokuhlushwa kweglucose yegazi.